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Red Cell Transfusion vs. Red Cell Exchange in Children with Sickle Cell Disease

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November 2014

Title: Red Cell Transfusion vs. Red Cell Exchange in Children with Sickle Cell Disease

Educational Objectives:

At the conclusion of this activity, participants will be able to:

  1. Understand the basis for transfusion thresholds in patients with sickle cell disease
  2. Define indications for simple transfusions and red cell exchange transfusion
  3. Discuss benefits vs. risks of simple transfusions and red cell exchange transfusion

Presenter: Haewon Kim, MD

Dr. Haewon Kim received her medical degree from Ewha Women’s University School of Medicine in Seoul, Korea. She completed fellowship in Hematology/Oncology at the Children’s Hospital of Philadelphia (CHOP). Dr. Kim is currently the Medical Director of the Apheresis Service and an attending hematologist at CHOP, and is an Associate Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. 


Dr. Kim is actively involved in the American Society for Apheresis (ASFA), and currently serves as the Chair of the Pediatric Apheresis Subgroup of ASFA. She is also involved in the Cellular Therapy Product Collection and Clinical Practice subsections of the AABB, and is an inspector for the Foundation for the Accreditation of Cellular Therapy (FACT). In 2000, 2007 and 2010, Dr. Kim served on the Writing group of the Clinical Applications Committee of ASFA responsible for the publication of therapeutic apheresis guidelines. 


Dr. Kim modified the standard RBC exchange protocol by incorporating isovolemic hemodilution. This concept and principle of isovolemic hemodilution-erythrocytapheresis have been adopted by Terumo, BCT in developing new RBC Depletion/Exchange Protocols on the Spectra Optia Apheresis System.